Biokinetic Modelling

AMBER can be used to model the transfer and fate of contaminants within the human body, following their ingestion.

For example, the Leggett biokinetic model for lead is used as the basis for assessments by the International Commission on Radiological Protection (ICRP). The Leggett model represents the age-dependent behaviour of lead, a heavy metal, in the human body after an initial amount of it has been deposited. It has been implemented in AMBER, illustrating how the software can be used to model the transfer of contaminants within the human body.

Lead against time graph

As part of a study into the chemical toxicity and radiological significance of intakes of uranium, Thorne and Wilson (2015) used AMBER to implement a biokinetic model of uranium, which combined the ICRP respiratory tract model (ICRP Publication 66), its systemic circulation (ICRP Publication 69) and the ICRP gastrointestinal tract model (ICRP Publication 30).